Paper Information

Title: 

THE HETEROGENEITY OF MEDIAL PREFRONTAL CORTEX IN APOMORPHINE-INDUCED STEREOTYPY BEHAVIORS

Type: POSTER
Author(s): ALIMORADIAN A.,BAHA ALDIN BEYGI F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Improvement of negative symptoms of psychosis by atypical drugs has been related to the medial prefrontal cortex (mPFC). mPFC is a heterogeneous area (prelimbic, infralimbic and anterior cingulated) with particular inputs and outputs with subcortical regions. mPFC is involved in the induction of locomotor hyperactivity, and clozapine inhibits this behavior. But role of mPFC in apomorphine-induced stereotypy behaviors is unclear. Stereotypy behaviors induced by apomorphine, a dopamine agonist, in animals are as animal In this work we studied stereotyped behaviors induced by APO injected in different subregions of mPFC, to show that the role of each subarea of mPFC in stereotypy behaviors is different.
Methods: We implanted cannula in prelimbic, infralimbic or anterior cingulated areas of mPFC. APO in five doses was microinjected, and then behaviors were recorded.
Results: There was a significant difference between three subareas. Sniffing, chewing and licking showed significant increase when APO was injected in the anterior cingulated, rearing and climbing with injection in the infralimbic, and yawing with injection in the prelimbic area showed significant increase (P<0.05).
Conclusion: These data could be discussed considering the connections of mPFC with limbic and striatum and also an inverse relationship between DA transmission in the cortical and subcortical dopaminergic systems.

 
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