Paper Information

Title: 

COMPARISON OF PERIPHERAL AND CENTRAL INJECTION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME SIGNS IN RATS

Type: POSTER
Author(s): ABBASI E.,ESMAEILI M.H.,PARIVAR KAZEM,YAGHMAEI P.,JAHANI HASHEMI H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: some report show that Matricaria chamomilla (MC) extract contains flavonoids, which exert benzodiazepine-like activity and inhibited the expression of abstinence syndrome in morphine-dependent animals.
Objective: to determine and comparison the effects of peripheral and central injection of Matricaria chamomilla extract on morphine withdrawal syndrome signs (MWS) in rats.
Methods: step 1: 30 Male rats (200-300gr) (n=6) were tested in 2 groups: control & morphine group (twice daily for 7 days) and divided in 4 sub groups: sahline group which was received only sahline and MC groups were received MC extract (10, 25, 50mg/kg ip) in day 7, 30 min befor naloxone administration. Step 2: 30 Male rats were surgically implanted with cannuale at the PGi and then they were tested in 2 groups as above. MC groups were received 1ul of MC extract (10, 25, 50ug/ul in to PGi) in day 7, 5 min befor naloxone administration. In the end of training day all groups were received naloxone (5mg/kg I.P) 3h after last injection of morphine and then the frequencies of withdrawal behavior (jumping, climbing) were assessed for 30 min.
Findings: Our results showed that PGi administration of MC extract with 25 ug/ul and ip administration of MC extract dose-dependently attenuate most of morphine withdrawal syndrome.
Conclusion: These results suggest that injection of MC extract in to the PGi & IP are helpful for morphine withdrawal syndrome treatment.

 
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