Paper Information

Title: 

COMPARISON BETWEEN NOCICEPTION IN MALE AND VARIOUS PHASES OF SEX CYCLE OF MICE IN PRESENCE AND ABSENCE OF NALOXONE

Type: POSTER
Author(s): KESMATI M.,ABBASI S.*,CHINIPARDAZ R.
 
 *DEPT. OF BIOLOGY, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Nociception is different in male and female. Some study indicated that these differences are related to sex hormones. Considering the various phases in sex cycle in female and the possible changes in opioid neuropeptids and nociception in CNS, the aim of this study was the comparison between this phenomenon in male and various phases of sex cycle of female mice (proestrous, oesterus, met estrous, Dioestrous) in presence and absence of opioid receptors activity.
Methods: Male and female mice weighing 30±3 g were used. Naloxone (3mg/kg) administered intraperitunealy in male and different phases of sex cycle in female mice and pain response time were evaluated by hot plate test.
Results: 1) Pain response time decreased significantly in male mice compared to proestrous and dioestrous phases of female mice. 2) Naloxone decreased pain response time in male and proestrous, oestrous phases. 3) The pain response time in male receiving of naloxone showed significantly difference in compared to proestrous, oestrous, and dioestrous phases.
Conclusion: The changes in hormones level in various phases sex cycle affects nociception mechanisms and sex hormones induced opioid receptors activity have effective role. 

 
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