Paper Information

Title:  INTERACTION OF SEROTONERGIC AND ANGIOTENSINERGIC SYSTEMS ON WATER INTAKE IN ADULT MALE WISTAR RATS
Type: POSTER
Author(s): AALAMI ROSTAMI SH.*,ORYAN SHAHRBANOU,ZARINDAST M.R.
 
 *DEPT. OF BIOLOGY, TARBIAT MOALEM UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Water intake is controlled by several mechanisms activated during dehydration. Structures such as subfornical organ, lateral hypothalamic area, OVLT, AV3V and pre optic nucleus have key roles on water intake. Angiotensin II is one of the most important neurotransmitters that play a role in body fluid homeostasis regulation. Serotonergic innervations originating in the mesencephalic raphe and receptors for serotonin have been identified throughout the lamina terminalis. In this study the interaction of i.c.v injection of serotonergic and angiotensinergic systems on water intake were investigated.
Methods: For i.c.v administration, a guid cannula was implanted in the right lateral ventricle of the adult male rats, weighting between 200-250g. After recovery period, the animals deprived of water for 24h and then drugs were injected and the volume of water intake was measured for one hour.
Results: The results showed that Risperidone (antagonist 5-HT2 receptor) (.25, .5, 1, 2µg/rat) and Losartan (antagonist AT1 receptor) (22.5, 45, 90µg/rat), decreased water intake in comparison with controls group (p<0.001). Fluoxetine (agonist 5-HT2 receptor) (5, 10, 20µg/rat), increased water intake in comparison with controls group (p<0.001) and preinjection of Losartan blockes the effects of Fluoxetine and Risperidone.
Conclusion: The present data indicated that serotonergic and angiotensinergic systems have a close interaction on water Intake in adult male wistar rats. Observations have shown that serotonin administered i.c.v actives a central angiotensinergic pathway, which activates AT1receptors to cause vasopressin release and the ascending serotonergic pathways are involved in the modulation of the thirst induced by dehydration and brain angiotensinergic stimulation.

 
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