Paper Information

Title: 

EFFECT OF TESTOSTERONE ON CARRAGEENONE INDUCED INFLAMMATION IN GONADECTOMIZED MALE RATS

Type: POSTER
Author(s): ZARIFKAR A.,SHARIAT M.,JAMEI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Different nociceptive and inflammatory responses to noxious stimuli in male and female animals imply that sex hormones may affect on inflammatory factors production and intensity of the inflammation. The aim of the current study was to evaluate the effect of testosterone administration on carrageenone induced inflammation in gonadectomized male rats.
Methods: In this research, 40 male Wistar rats, were divided into four groups (n=10). 1-The control rats without receiving any drug or surgical operation. 2-The sham-operated animals with surgical stress. 3-The gonadectomized rats, receiving 0.5 ml vehicle (olive oil) i.p. 4-The gonadectomized rats, receiving testosterone enantate (6 mg/100 gr body weight in 0.5 ml vehicle i.p.). At the sixth day after gonadectomy operation, inflammation was induced by injection of 1% carrageenone in the right hind paw of rats. Edematous paw volume as an index of inflammation was determined by immersing it into the mercury container. Weight of paw in the mercury was measured and then the paw volume was calculated in relation to specific gravity of mercury (13.6gm/ml). Data were statistically analyzed by SPSS and t-test.
Results: The results showed that edematous paw volume significantly was reduced in testosterone administrated gonadectomized rats compared to the control group (P<0.01).
Conclusions: It was concluded that high dose of testosterone decreased inflammation. Testosterone anti-inflammatory effect is probably due to inhibition of inflammatory factors (Interlukins) production or decrease in inflammatory factor receptors.

 
Keyword(s): 
 
Yearly Visit 21   tarjomyar
 
Latest on Blog
Enter SID Blog