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Paper Information

Title: 

L-ARGININE MODULATES MORPHINE-INDUCED CHANGES IN FOOD INTAKE OF MALE RATS

Type: POSTER
Author(s): SOUFIABADI M.*
 
 *
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Several studies have shown that the opiates alter some behaviors following central or peripheral administration in the rat. This study examined the effect of L-arginine on food intake after morphine treatment, during light phase.
Methods: 42 male spraugue-dawley rats (200-250g) were used among different 6 equal groups, and all agents were injected 6 H after fasting, then the animals put in test cages, where ad lib food consumption were monitored at each 15 min.
Results: we found that L-arginine (50 mg/ kg/ i.p) administration increases morphine (10 mg/ kg/ s.c.) induced changes in food intake in male rats. NG-Nitro-L-arginine methyl ester (L-NAME, 5mg/ kg/ i.p.), a specific inhibitor of nitric oxide synthase, reduces these effects.
Discussion: These results suggest that l-arginine -nitric oxide system can plays a role in the modulation of the effect of morphine - induced feeding behavior and probably clarify another pathway underlying food intake induced by opiates.

 
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