Paper Information

Title: 

THE EFFECTS OF DIFFERENT DOSES OF DIETARY SOY MEALS (WITH OR WITHOUT ISOFLAVONE) ON DEMENTIA INOVARIECTOMIZED ANIMAL MODEL OF ALZHEIMER'S DISEASE

Type: POSTER
Author(s): SAFAHANI M.*,ALI GHOLI H.,AMANI R.,SARKAKI A.,ZAND MOGHADAM A.,HAGHIGHIZADEH M.H.,BADAVI M.
 
 *NUTRITION DEPARTMENT OF AHWAZ JONDISHAPOOR OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Ovarian steroids are involved in reduction of cognitive disorders during neurodegenerative diseases especially Alzheimer's disease. These steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. The main objection of this study was to evaluate the effects of different doses of dietary soy meals (with or without isoflavone) on dementia in ovariectomized animal model of Alzheimer's disease.
Methods: First Wistar rats were ovariectomized (except for intact group). The animals were divided into 3 main groups. 1) Intact 2) Pre-treatment 3) Treatment. Pre-treatment groups received daily one type of five following diets 4 weeks before NBM electrical lesion: 0, 10 or 20gr soy with or without isoflavone from 30gr total diet. Treatment groups received one type of two following diets after NBM electrical lesion and before memory test: 0 or 20gr soy with isoflavone from 30gr total diet. The spatial learning and memory in Morris water maze were measured before and after electrical lesion. Rats were trained in water maze to find a hidden escape Platform. Rats received 6 blocks that each block consisted of 3 trials. Following acquisition trials, one probe trial were conducted in which the platform was removed.
Results: Animals receiving soy diet (with or without isoflavone) in both pretreatment and treatment groups significantly learned maze in higher level in comparison with other groups (P<0.05).
Conclusion: Soy probably has protective effect on cholinergic neurons related to learning and memory due to its antioxidative effect and or from its binding to estrogen receptors and mimics its protective effects.

 
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