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Paper Information

Title: 

COMPRATIVE STUDY OF THE EFFECT OF ULTRASOUND AND T-PA ON THROMBOEMBOLIC MODEL OF STROKE

Type: POSTER
Author(s): SHAABANZADEH A.,WANG C.X.,SHUAIB A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Object: Ultrasound has been used in neuroprotection after cerebral ischemia. Application of ultrasound may make strong fibrinolytic medications. In this study the effect of ultrasound alone or in combination with tissue plasminogen activator (tPA) on brain ischemic injury were examined and we studied whether US is protective in the brain injured ischemic.
Methods
: We performed four studies. In the first study, rectal and brain temperature were compared. In the second part, we studied whether US alone or in combination with tPA is neuroprotective in thromboebolic stroke. The infarction volume, edema and neurological deficits were after middle cerebral artery (MCA) occlusion. In the third and fourth study, we studied if US in combination with tPA can improve perfusion deficits or blood- brain barrier (BBB) permeability in rats after MCA occlusion.
Results: The results showed that temperature in the brain was approximately 0.5oC lower than the rectal temperature. Results indicate that US alone reduces the infarct volume by 30% compared to the control group (P<0.05).US improved neurological deficits and reduced brain edema significantly, (p<0.05). Result in the studies showed that administration of US significantly decreased perfusion deficits but not BBB permeability.
Conclusion: These studies suggest that US are protective in an embolic model of stroke and that is may be caused by decreased perfusion deficits in brain injured rats.

 
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