Paper Information

Title: 

ANTICONVULSANT EFFECTS OF PASSIFLORA INCARNATA IN THE MICE: INVOLVEMENT OF BENZODIAZEPINE AND OPIOID RECEPTORS

Type: POSTER
Author(s): SHARIATIRAD SH.*,NASIRIASL M.
 
 *FACULTY OF MEDICINE, QAZVIN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Recently, Passion flower (Passiflora Incarnata) has shown antianxiety and sedative effects in human. In this study, anticonvulsant effects of hydroalcoholic extract of passiflora, with commercial name of pasipay, was investigated in mice.
Methods: Anticonvulsant effects of pasipay were examined by using pentylenetetrazole model (PTZ). In this research pasipay, diazepam, and normal saline were injected intraperitoneally at doses (0.4-0.05 mg/kg), (0.5-1mg/kg), (10 ml/kg) respectively and after 30 minutes, PTZ (90 mg/kg, i.p) was injected to these mice. The time taken before the onset of clonic convulsions, the duration of clonic convulsions, and the percentage of seizure and mortality protection were recorded. For investigating the mechanism of pasipay, flumazenil (2 mg/kg, i.p) and naloxone (5 mg/kg, i.p) were also injected 5 minutes before pasipay.
Results: An ED50 value of pasipay in the pentylenetetrazole model (PTZ) was 0.2 mg/kg (%95 CL: 0.119, 0.408). In this model, pasipay at the dose of 0.4 mg/kg prolonged the onset time of seizure and decreased the duration of seizures compared to control (p<0.001). In this dose seizure and mortality protection percent was 100%. Flumazenil and naloxone could suppress anticonvulsant effects of pasipay.
Conclusion: From the above results it seems that pasipay may be useful for treatment absence seizure and these effects may be related to effect of it on GABAergic and opioid systems.

 
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