Paper Information

Title: 

INDUCTION OF CROSS TOLERANCE TO ANALGESIC EFFECT OF MORPHINE BY CHRONIC INTRATHECAL ADMINISTRATION OF CADMIUM IN RATS

Type: POSTER
Author(s): SHERAFAT M.A.,GHORBI J.,MOZAFARI S.,SATARIAN L.,JAVAN M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: cadmium as a cation is present in tobacco products especially in the cigarette. Several reports have showed that cadmium is able to increase tolerance to morphine analgesia. In the present study we have examined the development of cross tolerance to morphine analgesia following chronic administration of cadmium.
Methods: To induce morphine tolerance, morphine was injected intrathecally (15µg/rat) to male rats twice a day for five days. Cadmium (1nmol/rat) was injected intrathecally with same protocol for 5 days. The analgesic effect of morphine (15µg/rat) was measured using tail flick test on day 6.
Results: Interathecal administrated cadmium in days 1-4 induced significant analgesia. However, this analgesia decreased gradually. Morphine administration in this group of animals on day 6, failed to produce analgesia. Chronic administration of morphine for 5 days produced tolerance to its analgesic effect on day 6. In saline treated group, morphine injection on day 6 produced significant analgesia.
Conclusion: Our data showed that, i.t administration of cadmium is able to produce analgesia by and induces tolerance to analgesic effect of morphine.

 
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