Paper Information

Title: 

INTERACTION OF GLUCOSE AND ATP SENSITIVE POTASSIUM CHANNELS ON THE CONSOLIDATION OF MORPHINE INDUCED PLACE PREFERENCE

Type: POSTER
Author(s): SATARI NAEINI M.,ORYAN SHAHRBANOU,ZARINDAST M.R.,BABAPOUR V.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Morphine reported as an ATP- sensitive potassium channels opener. In the present study interaction of glucose and ATP sensitive potassium channels on the consolidation of morphine induced place preference in male mice have been investigated
Methods: Conditioned place preference method used to assess morphine reward and effects of glucose, glibenclamide and diazoxide on it.
Results: Intraperitoneally administration of different doses of morphine sulphate (0.5-7.5mg/kg IP) produced a dose-dependent conditioned place preference (cpp). However, the potassium channels opener and blocker diazoxide. (15, 30 & 60mg/kg IP) and glibenclamide (3, 6 & 12mg/kg IP), did not produce a significant place preference respectively. But post-training injection of glucose (2000mg/kg IP) and glibenclamide(6mg /kg IP) With on ineffective dose of morphine (0.5 mg/kg IP) produced significant cpp. The response of glibenclamide (6mg/kg IP) was attenuated by diazoxide (60 mg /kg IP). This dose of diazoxide alone had no effect on morphine (0.5mg/kg IP) induced cpp. Injection of diazoxide. (15, 30 & 60mg/kg IP) and glibenclamide (3, 6 & 12mg/kg IP) failed to changes on blood glucose level significantly.
Conclusion: It is concluded that glucose may be involved in morphine induced conditioned place preference through KATP channel mechanism.

 
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