Paper Information

Title: 

THE ROLE OF ADENOSINE A1 RECEPTORS IN POST-ICTAL INHIBITION IN AMYGDALA KINDLED RATS

Type: POSTER
Author(s): ZEYNALIPOUR T.,ABBASNEZHAD M.,SHEYBANI VAHID,MIRNAJAFIZADEH S.J.,PALIZVAN M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Post-ictal inhibition is a decrease in excitability that follows an epileptic seizure and decreases probability of new seizure occurrence. In this study the role of brain adenosine A1 receptors on post-ictal inhibition was investigated in amygdala kindled rats.
Methods: Animals were kindled by daily electrical stimulation of amygdala. Full-kindled animals were stimulated at the after discharge threshold intensity and seizure parameters were measured. 10, 30, 60 and 90 min after the first stimulation, rats were stimulated again and the percent of inhibition was measured (related to the response after the first stimulation) and considered as control data. Then the effect of intracerebroventricular injection of 1,3-dimethyl-8-cyclopenthylxanhine (CPT: a selective adenosine A1 receptor antagonist) on percent of inhibition was evaluated.
Results: Obtained results showed CPT (200 µM), decreased the percent of inhibition at 10 and 30 min after the first stimulation. However, microinjection of artificial cerebrospinal fluid (as the vehicle) had no significant effect on the inhibition percentage with compared to control data.
Conclusion: It may be suggested that activation of adenosine A1 receptors has an important role in post-ictal inhibition.

 
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