Paper Information

Title: 

EVALUATION OF AMNESIA INDUCED BY INTRACEREBROVENTRICULAR (I.C.V) ADMINISTRATION OF LITHIUM IN AN INHIBITORY AVOIDANCE TASK IN MICE

Type: POSTER
Author(s): SADAT SHIRAZI M.S.*,AHMADI SH.A.D.,ZARINDAST M.R.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, UNIVERSITY OF URMIA, URMIA
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Lithium is used as a stabilizer agent in mood disorders such as bipolar disorder. Studies have been shown that lithium caused memory deficit in patients treated with the drug.
Methods: In the present study, using inhibitory avoidance task (step-down model), memory impairment by lithium in male NMRI mice has been investigated.
Results: Immediate post-training administration of different doses of lithium (1, 2 and 4μg/mouse) impaired memory retention 24h later. Injection of the same doses of lithium 30 min after training showed impairing effect on memory more effectively. With injection of lithium 45 min after training its impairing effect was decreased and only at the dose of 4μg/mouse, memory impairment was observed.
Conclusions: The results show that post-training administration of lithium dose-and time-dependently impaired memory of inhibitory avoidance. It can be concluded that lithium impairs memory retention and its effect at 30 min after training was maximum response.

 
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