Paper Information

Title: 

STIMULATORYEFFECT OF CROCUS SATIVUS (SAFFRON) ON β2-ADRENOCEPTORS OF GUINEA PIG TRACHEAL CHAINS

Type: POSTER
Author(s): AHMADZADEH H.*,NEMATI H.,BOSKABADI M.H.,AFIAT M.
 
 *DEPT. OF PHYSIOLOGY AND PHARMACOLOGICAL RESEARCH CENTER, MEDICINAL PLANTS, GHAEM MEDICAL CENTRE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The relaxant effect of Crocus sativus t has been observed on smooth muscles including guinea pigs tracheal chain in previous studies. In this study the stimulatory effect of aqueous-ethanolic extracts of Crocus sativus on b-adrenoceptors was examined on tracheal chains of guinea pigs. The ß2-Adrenergic stimulatory effects of two concentrations of aqueous-ethanolic extract from Crocus sativus (0.1 and 0.2 g%) 10nM propranolol, and saline (0.2 ml) were tested by performing the cumulative concentration-response curves of isoprenaline induced relaxation of precontracted isolated guinea pig tracheal chains in two different conditions including: non incubated (group 1, n=9) and incubated with 1 µM chlorpheniramine (group 2, n=6). The results showed clear leftward shifts in isoprenaline curves obtained in the presence of only higher concentration of the extract in group 1, and its both concentrations in group 2 compared with that of saline in group 2. The EC50 (effective concentration causing 50% of maximum response) obtained in the presence of both concentrations of the extract in group 1 and 2 was significantly lower than that of saline (p<0.05 for all cases). The maximum responses obtained in the presence of both concentrations of the extract only in group 1 was significantly lower than that of saline (p<0.005 for all cases). All values of (CR-1) [(EC50 obtained in the presence of active substances I/EC50 obtained in the presence of saline) -1] obtained in the presence of higher concentrations of extract in group 1 and it’s both concentrations in group 2 were negative and were significantly different with those of propranolol whicf were positive (p<0.05 to p<0.001). The results of this study indicated a relatively potent stimulatory effect of the extract Crocus sativus on ß2-adrenoceptors. A possible inhibitory effect of the plant on histamine (H1) receptors also suggested.

 
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