Paper Information

Title:  THE MEASUREMENT OF EOSINOPHIL CATIONIC PROTEIN (ECP) LEVELS IN SERUM AND SPUTUM IN PATIENTS WITH ASTHMA
Type: POSTER
Author(s): KHAKZAD M.R.*,MIRSADRAEI M.,MESHKAT M.,KABOLI M.,FAZEL M.,KIANI N.
 
 *ISLAMIC AZAD UNIVERSITY OF MASHAD, MEDICAL FACULTY, MEDICAL RESEARCH CENTRE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Asthma is a common chronic disease, but the certain diagnosis caring of them. Activated eosinophils play an important role in pathogenesis of allergic asthma. ECP is one of (basic) granular proteins of eosinophils that are released from matrix of these cells. Serum ECP concentration might reflects severity of airway inflammation due to eosinophils.
Methods: In this study, fifty patients with allergic asthma diagnosis were selected. We have divided our patients according to status of disease activity into the exacerbation and stable groups; and according to severity of disease into the mild intermittent, mild-persistent, moderate and sever asthma by performing pulmonary functional test. Then sputum and serum were obtained from both patients and control group, contemporaneously. Total IgE and ECP level were measured in serum and sputum, and eosinophils percentages also were counted in sputum and blood samples. We also measured the ECP/EO ratio in this study.
Results:
Our data have been show that mean of serum and sputum ECP levels in all asthmatic groups is higher than healthy control group. A significant and positively correlation was found between serum ECP and sputum ECP levels into each groups. Also the mean of serum and sputum ECP levels in patients with mild-persistent asthma (30/25ng/ml) is higher than moderate (21/06ng/ml) and sever (18/19ng/ml) asthma. We found no correlation between asthmatic and healthy control subjects in ratio ECP/EO.
Conclusions: We have proposed that, may have been negative feedback mechanism for ECP production that to cause down regulation destructive effects of ECP in moderate and sever asthma.

 
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