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Paper Information

Title: 

INHIBITORY EFFECT OF CROCUS SATIVUS (SAFFRON) ON MUSCARINIC RECEPTORS OF GUINEA PIG TRACHEAL CHAINS

Type: POSTER
Author(s): NEMATI A.*,VAHEDI N.*,AMIRI S.,BOSKABADI M.H.
 
 *DEPT. OF BIOLOGY, ISLAMIC AZAD UNIVERSITY OF MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: The relaxant effect of Crocus sativus has been observed on smooth muscles including guinea pigs tracheal chain in previous studies. In this study the inhibitory effects of aqueous-ethanolic extracts of Crocus sativus on muscarinic receptors was examined on tracheal chains of guinea pigs.
Methods: The Inhibitory effects of three concentrations of the extract from (0.05, 0.1 and 0.2 g%), and safranal (0.63, 1.25 and 2.5 mg), 10 nM atropine, and saline on muscarinic receptors were tested by performing the cumulative log concentration-response curves of methacholine induced contraction of isolated guinea pig tracheal chains incubated with 1.4 µM indomethacin (n=8).
Results: The results showed clear parallel right ward shifts in methacholine-response curves obtained in the presence of atropine, 2 low concentrations of safranal and extract compared with the curves obtained in the presence of saline. The EC50 (effective concentration of histamine causing 50% of maximum response) obtained in the presence of atropine, two lower concentrations of safranal and all concentrations of the extract was significantly higher than that of saline
(p<0.01 to p<0.001). The EC50 obtained in the presence of higher concentration of the extract was also significantly greater than that of safranal (p<0.05). The maximum responses obtained in the presence of all concentrations of the extract was significantly lower than that of saline (p<0.01 to p<0.001).
Conclusion: These results indicated an inhibitory effect of
Crocus sativus at muscarinicreceptors but the mechanism of the inhibitory was non-competitive antagonism.

 
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