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Paper Information

Title: 

THERAPEUTIC ULTRASOUND INDUCED ENHANCEMENT OF TRANSDERMAL TRANSPORT OF INSULIN IN RATS

Type: POSTER
Author(s): MORTAZAVI S.M.J.,RAHMANI M.R.,DERAKHSHAN SH.,AGHAEI M.M.,SOLTANI M.,KESHAVARZ S.,POURGHOLAMI N.,BEHNEZHAD B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objective: Transdermal drug delivery is based on using ultrasound to increase percutaneous absorption of a drug. Enhancement of transdermal drug transport varies significantly from drug to drug and no enhancement has been found for several drugs.
Methods: For NPH insulin, fourteen rats were divided randomly into two groups of ultrasound exposure and sham exposure. For regular insulin, thirteen rats were divided randomly into two groups of ultrasound exposure and sham exposure. After inducing general anesthesia, animals were exposed or sham exposed to therapeutic ultrasound (3 MHz frequency, 1W/cm2 intensity, pulsed, 5 min duration). Five ml of Enraf-Nonius gel was used as the acoustic coupling medium. In both groups 5 units of either human or regular insulin was blended into 5 ml of acoustic gel. Blood sampling from animals orbits was performed 3 hours after exposure.
Results: Ultrasound significantly increased transdermal transport of both NPH and regular insulin in rats. For NPH insulin, the glucose level in irradiated rats was 79.75±9.05 mg/dL (mean ± SD), compared to 133.83±17.22 mg/dL in sham exposed rats. Ultrasound significantly increased transdermal transport of insulin in rats. For regular insulin, the glucose level in irradiated rats was 108.43±13.04 mg/dL (mean ± SD), compared to 183.33±53.67 mg/dL in sham exposed rats.
Conclusions: Transdermal transport of NPH or regular insulin can be enhanced effectively by therapeutic ultrasound. Further researches should be conducted to find an optimum frequency and intensity of ultrasound that cause the most significant enhancement of transdermal transport of insulin.

 
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