Paper Information

Title: 

HEPATOTOXICITY EFFECTS OF AQUEOUS EXTRACT OF ECHIUM AMOEMOM L IN RATS

Type: POSTER
Author(s): ZAMAN SOLTANI F.*,NASIRIASL M.,KARIMI R.,MAMAGHANIRAD P.
 
 *DEPT. OF ANATOMICAL SCIENCES, QAZVIN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Hepatotoxicity effects of Borago officinalis has been accepted due to pyrrolizidine alkaloid constituents. This study was performed to evaluate the hepatotoxicity effect of Echium amoemom L, indigenous to Iran, in rats.
Methods: In this research, fifty adult male Wistar rats were used. Experimental groups of rats received 100, 200 and 400 mg/kg doses of Echium amoemom aqueous extract for seven days by ip daily injections. Level of serum aminotransferases was evaluated in experimental and control groups. After routine histological procedures and preparation of slides, liver tissue samples were examined by light microscope.
Results: An LD50 value of extract was 2.03 g/kg (95% CL: 2.54, 1.62). Serum levels of alkaline phosphates and alanine transaminase were reduced significantly in experimental groups (p<0.05) in comparison with control group. Whereas there was no significant changes in aspartate transaminase values (p>0.05). In histological examination, fibrosis, inflammation and the other tissue and cellular lesions was not seen.
Conclusion: With regard to the results of the study and because there is no increasing in hepatic enzymes and no observation of any cellular and histological lesion, it seems that aqueous extract of Echium amoemom L has not hepatotoxicity effect.

 
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