Paper Information

Title: 

EFFECTS OF HYPERICUM PERFORATUM EXTRACT (HE) ON THE HEMATOLOGICAL AND LIVER PARAMETERS IN MALE WISTAR RATS

Type: POSTER
Author(s): ROUSHANAEI K.,ORYAN SHAHRBANOU,BABAPOUR V.,PARIVAR KAZEM,AHMADI R.,YAZDIAN M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Although hypericum perforatum has been subjected to extensive studies in the last decad.as a medical plant with well-known antidepressant and anti-stress effects, but. There are many questions about its side effects. The aim of this study is to evaluate some effects of hypericum perforatum extract (he) on the hematological parameters and liver function in adult male rats. Rats (220 20g) housed at 24C (12h L:12h D) and divided into following groups: The control which received 0.5ml normal saline (NS) at 7:00 am by gavage, the experimental groups received doses of 15, 30, 60, 120 and 240 mg/kg HE by gavage during 4 weeks. Then blood samples collected and hematological parameters and liver function tests were performed. Analysis of results show that effective doses of HE is 120mg/kg and had no significant effect on WBC count, compared to control (7.53+0.76 against 8.3+0.81). Also, RBC mean in group receiving 120mg/kg HE (7.36+0.07) compared to control (7.34 0.11) had no significant difference. In groups receiving 120 and 240mg/kg HE means of SGOT & SGPT significantly decreased. Therefore, concluded that HE has no significant side effects on hematopoietic tissues and liver of rats, The studies on the Effect of HE on HPA axis, relating to stress hormone(cortisal), are invest, igating.

 
Keyword(s): 
 
Yearly Visit 17   tarjomyar
 
Latest on Blog
Enter SID Blog