Paper Information

Title: 

STUDY OF CHONDROGENESIS ABILITY OF BLASTEMA TISSUE AFTER PLANTATION IN NEWZEALAND RABBITS INJURED MUSCLE

Type: POSTER
Author(s): REZAEIAN S.,HATAMI A.,MAHDAVI N.,ALIZADEH M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Blastema tissue is a group of undifferentiated cells that exists circulary in the pinna holes punched region that has a rapid distinction and division process. Brittberg (1999) showed that the chondrocytes driven from Autologous Chondrocyte Implantation (ACI) have good clinical results in restoration of cartilage. Immunohistochemistry showed that ACI replacement in vitro causes the dedifferentiation of Fibroblastic cells and creating chodrocyte cells. TGF-β that stimulate growth factor of chondrogenesis express by Chondrocyte. Transferred pinna Chondrocyte to the rabbit's injured muscle may function like ACI and express stimulation factore of cartilogenesis. Finally the new cartilage are generated and made by them.
Methods: The New Zealand white male sex rabbits (n=6) have been use, some circle-shape holes were made in pinna by specific forceps and after a determinate time, Blastema is made which is separated from the pinna, and then transfer and implant it to the plantation place. Finally, after the required time (10, 40, 60-day), it was attempted to sampling and preparing it for Histological study of the plantation place.
Results: In statistical analysis, it is used one-way anova and Duncan in order to examine the mean of microscopic chans of parameters of regenerative and inflammatory phases and to be significant or not to be were determined. In this research the rate of fibroblastic proliferation parameter was shown that difference between test and control group was significant (p<0.05).
Conclusion: In qualitative estimate, also, it is determined that if the plantation time be longer, chondrogenesis process gets more invigorated.

 
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