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Paper Information

Title: 

HERPES SIMPLEX VIRUS 1(HSV-1) INDUCES INHIBITION OF THE MITOCHONDRIAL ELECTRON TRANSPORT AND DECREASES TOTAL CELL RESPIRATION

Type: POSTER
Author(s): DERAKHSHAN M.,KASS GEORGE E.N.,CARTER M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Studies of interaction between viruses and mitochondria have shown that they can affect the mitochondria. Also linkage between human diseases and mitochondrial dysfunction has been revealed. We have screened different human viruses to observe their effect on the mitochondrial respiratory system. We found that herpes simplex virus type one (HSV-1) caused a decrease in total cell respiration. The addition of antimycin A (AA) to respiring HeLa cells completely blocked cellular respiration that means nearly all of the cellular consumption of oxygen is attributed to the mitochondria. In order to identify the site of electron flow block, we analyzed the integrity of the electron transport chain in the mitochondria of infected HeLa cells. Our results showed that following addition of succinate, a large stimula­tion of oxygen consumption was induced that was subsequently blocked by antimycin A. In contrast, following HSV-1 infection, succinate didn't induce such stimulation. This suggested that electrons added at complex II couldn't flow to complex III and indicates that mitochondrial function is deeply affected during HSV-1 infection.

 
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