Paper Information

Title: 

MEASUREMENT OF SOLUBLE TOLL-LIKE RECEPTOR 2 LEVEL IN ALLERGIC ASTHMA

Type: POSTER
Author(s): TEHRANI M.,SANKIAN M.,KHAKZAD M.R.,MIRSADRAEI M.,VARASTEH A.A.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Toll-like receptor (TLR) stimulation can lead to the activation of both innate and adaptive immune responses. Recently there have been some reports indicated the role of membranous form of TLR2 in asthma pathogenesis. This study aimed to compare concentration of soluble form of TLR2 (sTLR2) in serum and sputum samples from patients with allergic as well as non-allergic asthma.
 Methods: Serum and sputum samples were obtained from patients both allergic (n=20) and not allergic (n=14) asthma. All subjects were otherwise healthy. The subjects were classified to four groups according to
National Asthma Education and Prevention Program (NIH 1997). Eosinophile count of peripheral blood and eosinophilic cationic protein level of serum were measured in all subjects. sTLR2 levels were determined using ELISA assay.
Results: The mean eosinophile count was 5% in allergic and 1.33% in non-allergic asthma. The mean concentration of ECP was 25.49 in allergic and 15.21 in non-allergic asthma. The mean optical density of sTLR2 was for patients in stage 2, 3 and 4 were 0.307, 0.245 and 0.104, respectively. The mean optical density of sTLR2 was o.219 in allergic and 0.274 in non-allergic asthma.
Conclusion: The mean optical density of sTLR2 shows a negative correlation with the stage of the disease, therefore, it seems that sTLR2 has a regulatory effect on asthma pathogenesis.

 
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