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Paper Information

Title: 

PRETREATMENT EFFECT OF MORPHINE ON SERUM BDNF LEVEL DURING CARRAGEENAN INDUCED INFLAMMATION

Type: POSTER
Author(s): HATAMI H.,ORYAN SHAHRBANOU,AHMADIANI A.A.H.,SEMNANIAN S.,SEYED N.,KAZEMI B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Brain- derived neurotrophic factor (BDNF) is a member of the neurotrophic family. BDNF is known to play an important role in regulating synaptic plasticity and a role in altering pain thresholds has been proposed both for inflammatory and naturopathic pain. Evidences indicate that nociceptor- derived BDNF plays a role in mediating inflammatory pain caused by carrageenan and formalin.
Methods: Inflammation was induced by 0.05 ml of 3% W/V solution of lambda carrageenan in saline injected into the plantar surface of the rat hind paw and saline in an equal volume in the contralateral paw. Oedema of injected paw was measured during 6 h period after the carrageenan injection. Animals were killed with decapitation 4h after carrageenan injection and trunk blood was collected. BDNF was assayed in rat serum using the ELISA kit.
Results: Administration of carrageenan elicited a significant decrease in BDNF serum levels at the same time. Pretreatment of morphine did not significantly alter circulating BDNF levels during carrageenan induced inflammation.
Conclusions: The anti-inflammatory effect of morphine did not go along with decreasing BDNF level during inflammation.

 
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