Paper Information

Title: 

IMMUNOCHEMICAL CHARACTERIZATION OF SALSOLA KALI POLLEN EXTRACT

Type: POSTER
Author(s): ASAREHZADEGAN M.A.*,SANKIAN M.,VARASTEH A.R.
 
 *IMMUNOBIOCHEMISTRY LAB., IMMUNOLOGY RESEARCH CENTER, BOU-ALI RESEARCH INSTITUTE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Epidemiological studies carried out in different countries indicate the prevalence of respiratory allergy as 15-30%. Aeroallergens play a major role in the pathogenesis of respiratory allergic diseases, particularly asthma and rhinitis. The inhalation of Salsola kali (Russian thistle) pollen an important cause of allergic respiratory symptoms in Iran. The objectives of this study were to evaluate of allergenic composition of S. kali pollen.
Methods: A population of 30 individuals with specific IgE-mediated allergic symptoms and positive skin tests to S. kali were included in the study. The antigenic and allergenic profile of S. kali Pollen extract was evaluated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblot.
Results: 10 distinct protein bands were recognized by human IgE-specific antibodies in the immunoblot from the SDS-PAGE gel. Molecular weights of these allergens ranged from 121 kDa to 91 kDa.
Conclusion: 21 patients with a positive skin test to a standardized S. kali extract had a positive reaction to an allergen with a molecular weight of approximately 66 KDa. It is appear this protein is one of the major allergen in S. kali pollen extract.

 
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