Paper Information

Title: 

STUDY OF LEVAMISOLE EFFECT ON IMMUNE SYSTEM IN RAT

Type: POSTER
Author(s): GHAVAMI S.,KHAYAT NOURI M.H.,SEDIGH ETEGHAD S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Levamisole is one of anti parasitic drugs which have wide usage in medicine. Studies shown that, in addition of anti parasitism effect, this drug has immune stimulant effect in several animals. The aim of this study is scrutiny of levamisole effect on Rat immune system.
Methods: In this study we used of 20 males rat mice (n=10 for each group). First group received physiologic serum and in another group used of drug in
2 mg/kg  dosage by one day interval and during 3 weeks, orally. In next step after blood sampling and purring them serum, laboratory analyses included, Hematocrit, differential white blood cell count, phagocyte activity (number), total protean, albumin and gamma globulin is done.
Results: Result shown that, in levamisole group into the physiologic serum group has significant increasing in differential white blood cell count and gamma globulin level (p<0.001), the number of lymphocytes and phagocyte activity have significant increasing too (p<0.05). But in hematocrit, total protein and albumin level not significant changes seen.
Discussion: levamisole has immune stimulant effect in Rat and this effect probably acting via increasing lymphocyte number and phagocytosis and gamma globulin level in blood.

 
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