Paper Information

Title: 

IMMUNO-BIOCHEMICAL EVALUATION OF EFFICACY BY NITRIC OXIDE SYNTHETIC METABOLITE (S-NITRATE) ON MURINE MALARIA CAUSED BY PLASMODIUM BERGHEI

Type: POSTER
Author(s): ESMAEILNEZHAD S.,NAHRAVANIAN H.,HAJI HOSSEINI R.,KHATAMI SH.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Malaria is one of the most important and commonest parasitic diseases in the world, which is caused by a protozoan parasite of the genus Plasmodium. Potential effector mechanisms of immunity in malaria include antibodies, macrophages, cytotoxic T-cells, cytokines and a variety of soluble mediators. In addition to numerous cytokines, nitric oxide (NO) is thought to be an important mediator and critical signaling molecule of malaria immunopathology and a target for novel drug therapy and immunomodulation. This study has investigated the involvement of NO and reactive nitrogen intermediates (RNI) in murine malaria caused by Plasmodium berghei, in order to evaluate whether changes in NO production and actual level of RNI are beneficial or detrimental to the host. Data of both RNI values resulting from Griess microassay (GMA) and microelements concentrations by biochemical methods indicated the involvement of NO in malaria infected animals in comparison with that of control group. The variation of RNI levels are related to immuno-biochemical activities and pathophysiological signs. It is highlighted that NO may has protective or pathologic effects which need further investigations.

 
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