Paper Information

Title: 

HEALING EFFECT OF HYDROALCOHOLIC EXTRACT OF BANANA PEEL IN SKIN WOUND OF RABBIT

Type: SPEECH
Author(s): HEMATI A.A.,MOHAMMADIAN B.,ALAHYARI N.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Wound healing is a natural reaction to injury which restores the tissue integrity including phases of inflammation, proliferation, angiogenesis and remodeling. In this study the healing effect of hydralcoholic extract of banana (Musa accuminata) peel was investigated on open skin wound. Newzealand rabbits of either sexes were used. Hairs of lower back and left flank of animal was completely shaved, animal was held in standard crouching position, Full-thickness wound (20x20 mm) was made by excising the skin using scaplel blade and forceps. Every day the outline of each wound was traced using transparent plastic sheet. Then area of wounds was determined. First group was left without treatment, second group was treated with eucerin, in third group phenytoin cream 1% was used as standard control, in other groups different concentrations of hydralcoholic extract of banana peel (3, 5, and 10 % w/w) in eucerin base was applied twice daily. Area of wound in first day was considered as 100% and area of subsequent days were compared with initial day. Percentage of healing was calculated by subtracting the percentage of area from 100. Tissue sample from wound area was prepared and stained with H&E for histopathologic studies. Healing in no-treatment and eucerin groups lasted 21 days and phenytoin caused a complete healing within 17 days. In banana peel ointment treated groups healing was occurred in 15, 14 and 12 days respectively. On the end of treatment of 10% banana group it was significantly (P<0.01) different from other groups in terms of healing. The result of this study confirms that hydralcoholic extract of banana peel have a good potential of reducing the time for wound healing even better than phenytion.

 
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