Paper Information

Title: 

COMPARATION OF EFFECTS OF RAW AND COOKED GARLIC ON BLOOD GLUCOSE ON STREPTOZOTOCIN -INDUCED DIABETIC MOUSE

Type: SPEECH
Author(s): HASHEMINIA M.,MAHJOUR A.A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Garlic has long been used medicinally, most recently for its cardiovascular, antineoplastic, antimicrobial and antidiabetic properties. Sulfur compounds, including allicin, appear to be the active components in the root bulb of the garlic plant.
Aims: In the present research the effect of raw and cooked garlic on blood glucose on Streptozotocin -induced diabetic mouse were studied
Methods: In this study 40 female rats (180-200g) were divided into four groups of tens. Diadetes mellitus was induced in 3 out of 4 groups using intrapritoneal injection of 50 mg/kg BW Streptozotocin. The first group was fed a diet containing 10% BW raw garlic , another group was fed a diet containing 10% BW cooked garlic and the third group(positive control) received ordinary diet .The remaining non-diabetic group (negative control) received ordinary diet. Blood glucose was measured every morning (after 10h fasting) with glucometer for 2 weeks. On the last day pancreas and liver removed for histopathological study. The data were evaluated by one-way analysis of variance (ANOVA) and pancreatic and hepatic sections stained with H&E.
Results: Thr results have shown that the garlic reduces blood glucose compared with the control group and the effect of cooked garlic is better than raw garlic. Morphologic factors in microscopic view were significantly changed in comparison with the control negative group, but the same did not show significant change between treated and untreated diabetic rats.
Conclusion: According to the better effects of cooked garlic compared to raw garlic in this study, the other researchers can analyze the cooked garlic and evaluate the effective matter inorder to decrease blood glucose.

 
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