Paper Information

Title: 

INTRODUCING AN EXPERIMENTAL MODEL FOR ABSENCE EPILEPSY (WAG/RIJ RATS) AND COMPARING THEIR SPIKE-WAVES (SWS) WITH BRAIN DISCHARGES OF NORMAL WISTAR RATS AND FIRST GENERATION OF THESE TWO STRAINS

Type: SPEECH
Author(s): MOGHIMI A.*,HADAD F.,BEHNAM RASOULI F.,MOLAZADEH Z.,SHIEI R.
 
 *
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Absence epilepsy is a neurological defect with fast and reversible periods of unconsciousness and generalized paroxysmal electrical activities (3-4 HZ). Finding a genetic model for absence epilepsy has been an important aim of many researchers working in the field of experimental epilepsy. Wag/Rij rats are an absence prone strain that were transported from NICI Institute (Nijmegen Univ., Netherlands) to physiology lab. of Ferdowsi University. The aim of this research was determining and comparing the brain electrical activities of Wag/rij and normal wistar rats and first generations (breeding of male Wag/rij with female normal wistar rats). After implanting electrodes (stereotaxic method) in the frontal cortex of parents and first generation (F1) of all experimental rats and recovery period, EEGs were recorded and their SWs compared with recordings from normal wistar rats. Results show that absence typical SWs with repeating patterns (3-4 HZ) in parents and first generation of Wag/rij rats were obvious but only in 1% of old wistar rats were found without a stable pattern. Also brain cortical activity of F1 rats showed significant decrease in their generalized SWs discharges (P<0.01), indicating the unstability of the electrical patterns of absence after breeding of these different stains and emphasizes usefulness of Wag/rij rats as a model for absence epilepsy researches. More researches are going to determine physiopathology of SWs and find new effective substances against this form of epilepsy.

 
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