Paper Information

Title: 

COMPARE OF NEUROPROTECTIVITY OF DEPRENYL BETWEEN OF MPSS IN HEMI-SECTIONED SPINAL CORD INJURY

Type: SPEECH
Author(s): ASHRAFI OUSALOU M.*,ALTARIHI T.
 
 *ANATOMICAL SCIENCE DEPARTMENT, MEDICAL SCIENCE FACULTY, TARBIAT MODARRES UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Many suffer from traumatic spinal cord. In this study, on animal model was developing to study the traumatic spinal cord injury, which then was used to evaluate the study the neuroprotectivity of deprenyl and spinal cord injury.
Methods: The animals were divided into 5 groups. The first one as control (N-TR), the second group was sham operated. The third group was hemi transected without receiving deprenyl the fourth group hemi-section received2.5 mg/kg deprenyl and fifth group received mpss for 21 days by IP injection (TR). The spinal cord of the adult sprague-dawley rats was hemi-sectioned at the level of T10. All groups were evaluated using BBB test. After 21 days the L4-L6 segments were serial sectioned and stained with Cresol-fast violet. The motoneurons were counted and statistically analyzed.
Results: The results demonstrated that motoneurons were protected significantly in 4th group. The BBB test in the 4th group compared with the fourth group, showed significant improvement.
Conclusion: Deprenyl can protect the motoneurons in traumatic spinal cord injury.

 
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