Paper Information

Title: 

IN-VITRO STUDY OF ANTI-PROLIFERATIVE EFFECT OF COBALT COMPLEX LIGANDED SALEN ON CANCER CELLS

Type: SPEECH
Author(s): MOLAZADEH S.,MOGHADAM MATIN M.,BAHRAMI A.R.,BEHNAM RASOULI MORTEZA,ESHTIAGH HOSSEINI H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

A special cell line which is derived from human prostate tumor and cultured in vitro conditions is NTERA2. These cells are pluripotent and can differentiate to many kind of differentiated cells. The proliferative potency of these cells is very high and these cells are stuitable for anticarcinogenic studies. In the present research the cytotoxic effect of cobalt complex with salen ligand, which is synthetized by salicylaldehyde interaction was investigated. The anti-proliferative /anti-carcinogenic effects of cobalt complex with salen ligand were evaluated by MTT assay, which is based on the functional feature of mitochondrial enzymes after determination of the growth curve of NTERA2 cells and the level of Oct4 mRNA, which is a marker of undifferentiated cells.

 
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