Paper Information

Title: 

STUDY OF THE ANTI-INFLAMMATORY EFFECT OF PLANTAGO MAJOR SEED EXTRACT ON RAT PAW EDEMA

Type: SPEECH
Author(s): MOTEVALIAN M.*,MOTAHARI M.,SHIRI M.
 
 *PHARMACOLOGY DEPARTMENT, MEDICAL SCHOOL, IRAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Inflammation is a common nonspecific manifestation of many diseases. The common chemical anti-inflammatory drugs have numerous side effects, in comparison with their herbal drug counterparts. The study of plants that have been traditionally used as anti-inflammatory should still be seen as a fruitful and logical research strategy, in the search for new anti-inflammatory drugs. Plantago major, from the family Plantaginaceae, is extensively cultivated in most regions of the world. It is known to have several pharmacological effects, such as anti-inflammatory and analgesic effects. In this study, we examine the anti-inflammatory effect of Plantago major seeds. For evaluation of this effect, the paw inflammation model was used through subcutaneous injection of 2.5% formalin to the paw of male rats, and inflammation was assessed by pletismometer on the first day (acute inflammation) and during 7 day after (chronic inflammation) formalin injection. Plantago extract in various doses (100, 300, 1000 mg/kg) were compared with Sodium Salicylate (300 mg/kg) and Distilled Water, in intra-peritoneal injections. Plantago seeds extract of 1000 mg/kg (p<0.003) and Sodium Salicylate of 300 mg/kg (p<0.003), both had significant acute anti-inflammatory effects without any significant difference between them. Plantago seeds extract of 1000 mg/kg had significant chronic anti-inflammatory effect (p<0.05) on 4th, 7th and 8th days but this effect was only significantly seen on 4th day for Sodium Salicylate and other extracts had no significant chronic effect. Based on our results, Plantago major seeds, have dose-dependent acute and chronic anti-inflammatory effects.

 
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