Paper Information

Title: 

THE EFFECT OF AMARANTHUS CAUDATUS HYDROALCOHOLIC EXTRACT ON ATHEROSCLEROSIS IN RABBIT

Type: SPEECH
Author(s): KABIRI NAJMEH,MADANI H.,ASGARI S.,MAHZOUNI P.,EBRAHIMIPOUR H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

OBJECTIVES: Cardiovascular and atherosclerosis that is caused by a gradual deposition of lipids in muscular arteries remain a major cause of mortality word wide. In this study the effect of Amaranthus caudatus hydroalcoholic extract on atherosclerosis was investigated in rabbit.
METHOD: 20 male rabbits were randomaly distributed in to four groups of five each. Animals in group 1 received regular rabbit chow, in group 2 received HCD, in group 3 received Amaranthus hydroalcoholic extract and in group 4 received HCD and Amaranthus hydroalcoholic extract (150mg/kg wb) respectively for 60 days. In the beginning and final stage of the experimental period, blood samples were taken to measurement concentration of cholesterol, TG, HDL, LDL and AI. The aorta was removed for assessment of atherosclerotic plaques.
RESULTS: The results indicate that extract increase significantly (P<0.05) the level of HDL and reduce significantly (P<0.05) the levels of TC, TG, LDL, OX-LDL, hs-CRP and AI in group compared with group hypercholesterol. Severity of aortic atherosclerosis and degree of atherosclerotic plaque in groups that treatment with extract reduce significantly (P<0.05) compared with group2.
CONCLUSION: The reduction of atherognic lipoproteins by Amaranthus caudatus hydroalcoholic extract can be due to the antioxidant effect of this extract.

 
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