Paper Information

Title: 

TREADMILL RUNNING REVERSES RETENTION DEFICIT INDUCED BY MORPHINE

Type: SPEECH
Author(s): ALAEI H.A.*
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Human and animal studies have suggested that exercise has benefits overall health and cognitive function. The aim of this study was to investigate the effect of treadmill running on learning and memory and levels of glutamate in the dentate gyrus of hippocampus in intact and morphine treated rats.
The passive avoidance learning was measured in different time intervals (1, 2 and 24 hours as well as 1 week and 1 month). Treadmill trained and corresponding control rats went through spatial learning process on a Morris water maze for 8 days. The time to reach the platform (latency), the length of swim path, and the swim speed were used for the evaluation of spatial learning. In vitro microdialysis also was used to this study for measuring the level of glutamate during one hour. Four groups of rats were included as follows: control, exercised-saline, morphine-treated and exercised-morphine treated groups. The data obtained was analyzed using unpaired Students t-test and ANOVA test.
The results showed that the avoidance learning was significantly increased in exercise-saline and exercise-morphine treated groups as indicated by the increased total time delay to entry in the dark box compared with the control groups (p>0.05). Our results also showed that physical activity produced a significant enhancement in spatial learning, with a decreased path length (p>0.05) latency (p>0.05) and increased the swim speed to the platform in exercise- morphine treated in comparison with control and morphine treated groups in Morris water maze. Furthermore, release of glutamate were significantly increased in dentate gyros of the exercised-morphine treated rats in comparison with other groups (p>0.05). In conclusion our findings suggest that the morphine impaired the avoidance learning and short-term memory and this was reversed by the treadmill running. But combination of exercise and morphine increased spatial learning and concentration of glutamate. It could be mediated through the activation of glutamate receptors in the dentate gyros and glutamate may play an important role in potentiation of learning.

 
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