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Paper Information

Title: 

EFFECT OF MORPHINE AND PHYSICAL ACTIVITY ON GLUTAMATE CONCENTRATION IN DENTATE GYRUS OF HIPPOCAMPUS IN HEALTHY AND MORPHINE DEPENDENT RATS: A MICRODIALYSIS STUDY

Type: SPEECH
Author(s): AZIZI MALEKABADI H.*,ALAEI H.A.,ORYAN SHAHRBANOU
 
 *DEPARTMENT OF EMPIRICAL SCIENCE, BASIC SCIENCE, ISLAMIC AZAD UNIVERSITY, KHURASGAN BRANCH, ESFAHAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objective: In this research effects of treadmill running on variation of glutamate concentration from hyppocampal dentate gyrus in the intact and morphine dependent rats have been reported
methods: Twenty-eight healthy male rats with weighting about 250gr were assigned to four groups as follows: control, morphine, Physical activity, morphine with Physical activity. Intraperitoneal injection of morphine with increased doses of respectively 10, 20 and 40mg/kg, were applied to make rats morphine dependent. Treadmills running were performed in a ten-day period. Microdialysis, the anesthetized rat was placed in stereotaxis apparatus and the micodialysis probe was placed in hippocampal dentate gyrus. Then aCSF were entered into probe by microinjection pump with speed of 2µl/min and the output of the probe was collected and Glutamate concentration was measured by HPLC method and the results were statistically analysed.
Results: Glutamate concentration with Physical activity is elevated significantly compared to other groups (*P<0.05).
Discussion: Perhaps morphine would make consistent changes in transmission of glutamatergic synapses and increase its extracellular amount and Physical activity would decrease its extracellular amount through the elevation of glutamate transmitters (GLTs). Morphine and Physical activity, probably with a synergism effect cause a great increase in extracellular glutamate at the dentate gyrus.

 
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