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Paper Information

Title: 

DRUG DISCOVERY PAST, PRESENT AND FUTURE

Type: PAPER
Author(s): SHAFIEI A.*
 
 *DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY AND PHARMACEUTICAL SCIENCES RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN 14174, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Before the 20th century medicines consisted mainly of herbs. In the mid-nineteenth century efforts were made to isolate the active compound. Chemists made literally thousands of analogues of the active compound to improve what nature had provided. The mechanism by which a drug worked at the molecular level was rarely understood and drug research very much focused on what is known as the lead compound, so that, the active principle isolated from the plant. In recent years medicinal chemistry has undergone a revolutionary change. Rapid advances in the biological sciences have resulted a much better understanding of how the body functions at the cellular and molecular levels. Therefore, most research begins by identifying a suitable target in the body and designing a drug to interact with the target. Generally in drug discovery and drug development the following stages are considered: 1- choose a disease, 2- choose a drug target (receptor, enzyme, a nucleic acid), 3- identify a bioassay, 4- find a lead compound, 5- isolate and identify the lead compound, 6- determine structure-activity relationship (SAR), 7- identify the pharmacophores, 8- improve target interactions, 9- improve pharmacokinetic properties, 10- study drug metabolism, 11- test for toxicity, 12- design a manufacturing process, 13- carry out clinical trials, 14- market the drug. In the present presentation points 1 to 14 will be discussed.

 
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