Paper Information

Title: 

EFFECT OF EXERCISE ON MEMORY AND MORPHINE ADDICTION

Type: PAPER
Author(s): ALAEI H.*
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCE, ISAAC, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Regular physical exercise promotes neural health and function. Both animal and human studies have shown that exercise improve cognitive function (Sutoo et al., 2003). It has been shown that physical activity facilitates recovery from injury and improves cognitive function (Fordyce et al., 1993 <http://www20.uludag.edu.tr/~hakan/sbtd/vol2/n3/4/v2n3-4ref.htm>). Physical exercise also influences the central dopaminergic, noradrenergic, and serotonergic systems. A number of studies have examined brain noradrenaline (NA), serotonin (5-hydroxytryptamine, or 5-HT), and dopamine (DA) with exercise (Schinder et al., 2000; Alaei et al., 2003). Acute exercise influences on extra cellular DA, NA, GLU, and GABA levels (Leung et al, 2006). Other peoples found that opiate abuse causes long-lasting neural changes in the brain that underpin the behavioral abnormalities associated with cognitive deficits, tolerance, and dependence (Williams et al., 2001). Recently, a modification in neuronal plasticity at glutamatergic synapses has been suggested to account for the neural changes in drug abuse (Nestler, 2001). Importantly, increasing evidence demonstrates that opiates significantly alter glutamatergic synaptic transmission and neuronal plasticity in hippocampus (Pu et al., 2002). Previously we also showed that acute morphine injection increase level of glutamate in the VTA nucleus via AMPA receptors (Alaei et al., 2003); and treadmill running reversed short term memory -deficit by morphine in rats (Alaei et al., 2006). Our results together with others emphasize the role of treadmill running in the improvement and promotion of learning and memory in intact rats. Memory deficit caused by morphine was also reversed by the treadmill running, suggesting that physical activity enhanced learning and short-term memory functions probably via the activation of release of glutamate neurotransmitters and others neurotransmitters in some nuclei in the brain.

 
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