Paper Information

Title:  CONCEPTS AND METHODS IN CLASSICAL AND SYSTEMS BIOLOGY
Type: PAPER
Author(s): NOURBAKHSH F.*
 
 *
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Molecular biology focuses on studying the structure and function of individual biomolecules (i.e. genes and proteins), one or few at a time. Classical approaches, which still dominate biology labs all around the world, have been extremely fruitful over the last few decades and have helped identify the structure, function and interactions of multitudes of genes, proteins and other biomolecules. In the context of biomedical sciences, these traditional approaches have contributed significantly to our knowledge about disease mechanisms and have led to the development of different therapeutic strategies for human diseases. However, understanding the behavior of complex biological systems is believed to require a “systems-level” approach, which allows the genes, molecules and pathways to be viewed in the bigger context of the entire physiology of the cell/organism. The advent of new genomic, proteomic and metabolomic research technologies have allowed biologists to analyze multiple nodes (e.g. genes or proteins) in interconnected networks of molecules in different physiologic or pathologic states of an organism at once. When followed by appropriate statistical analyses and mathematical modeling’s, this can lead to the discovery of fundamental, system-level principles underlying the behavior of complex biological systems. This so-called “systems biology” with its broad perspective together with its emphasis on quantitative analyses of biological and pathological processes holds tremendous promise in identifying new targets for modulation of complex systems' behaviors; i.e. therapeutically intervening at a system level to modify a pathological behavior.

 
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