Paper Information

Title: 

SURVEY OF EFFECT IV INJECTION OF SODIUM PENTOBARBITAL ON HEAMATOLOGICAL AND SERUM BIOCHEMICAL IN SHEEP

Type: POSTER
Author(s): MEHRABANPOUR M.J.,MOSTAGHNI KH.,PANJEH SHAHIN M.R.*,AMIN LARI M.
 
 *SHIRAZ UNIVERSITY OF MEDICAL SCIENCE, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Barbiturates are extensively used for animal’s anesthesia. Barbiturates pass through blood brain barrier and block endoplasmic reticular activating system, causing its depression and resulting in anesthesia. As these drugs influence biochemical and blood factors. Therefore, this study was undertaken to evaluate the effect of this drug on heamatological factors and some blood electrolytes such as sodium, potassium, calcium, glucose and urea.
Methods: Experiments were carried out on five healthy nonpregnant Iranian sheep, aged 1-1.5 years old, weighting 25 to 40 kg. Sheeps were maintained in pens and fed a diet of hay and water, but were starved for 12 hours before experiment. Blood sample were taken from the jugular vein before and after the induction of anesthesia by 25mg/kg sodium pentobarbital.
Results: The results indicated that a significant decrease in Hb, RBC and PCV occurred (p < 0.05) during the anesthesia by IV injection of Na pentobarbital, but other blood biochemical factors did not change significantly. WBC changes after IV injection increased but not significantly.
Conclusion: reduction in hemoglobin and haematocrite could be the consequence of spleen dilation and storage of RBC in dilated spleen. This dilation of spleen reached to its maximum level at 20 to 30 minutes after drug being used and at 190 minutes reached to its normal level.

 
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