Paper Information

Title: 

EPTURUS ENVENOMATION IN RAT

Type: POSTER
Author(s): PIPELZADEH M.H.,DEZFOULIAN A.A.R.,GHALAMBOR A.H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Hemiscorpious lepturus is the most dangerous scorpion species in Iran, and there is not standardized protocol for its treatment and the effectiveness of anti-venom treatment is not clearly established. The aim of this work was, therefore, to assess the optimal time and the dose need to be administered following envenomation in experimental conditions in rat.
Material and Methods: In the first series of experiments for evaluation of the optimal effective dose of the anti-venom: The rats were divided into three groups to which 0.1, 0.3 and 0.5 ml of the anti-venom was administered subcutaneously immediately after administration of 10
mg of the venom, a dose that was preliminarily found to produce toxic effects after one week of administration. Histological evaluation of kidney sections and urinary analysis were undertaken after one week. In the second series of these experiments, in order to find the optimal time of administration of the anti-venom dose that was found to be effective in the previous series of experiments four groups of 5 rats were treated with anti-venom at 0.5, 1, 2 and 3 hours after envenomation with 10 mof the venom. Similar histological evaluations and urinary analysis were made.
Results: the optimal dose of anit-venom serum that was found to be effective in preventing toxic effects of the venom was 0.3 ml.

 
Keyword(s): 
 
Yearly Visit 6   tarjomyar
 
Latest on Blog
Enter SID Blog