Paper Information

Title: 

NEPHROTOXICITY AND TUBULAR CELL DEATH BY ACETAMINOPHEN OVER DOSE IN BALB/C MOUSE

Type: POSTER
Author(s): JALALI M.,NIKRAVESH M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Acetaminophen (paracetamol) is an analgesic/antipyretic drug that is widely prescribe. Previous studies shown that the over dose of acetaminophen can cause hepatotoxicity and nephrotoxicity in humans and experimental animals. However, whether this acetaminophen-induced nephrotoxicity involves apoptotic cell death in addition to necrosis is unknown. The goals of this investigation were evaluate the effect of acetaminophen on renal tubules in an animal model.
Methods: For this study 18 Male Balb/c mice 2 mount age divided to 3 groups (experimental 1, 2 and control). Group 1 were received a therapeutic dose of acetaminophen (48.5 mg/kg) for 10 days. Group 2 received the double therapeutic (over) dose (97 mg/kg) of acetaminophen as the same periods and control group remained untreated.
Results: Histological study of diverse types of kidney cells showed cell death in proximal and distal tubules of kidneys in experimental group 2 (treated by 97 mg/kg of acetaminophen), while experimental group 1 and control don't showed any histopathological changes.
Conclusion: Histological examination of kidney sections in experimental group 2 revealed numerous apoptotic nuclei across proximal and distal tubules. Collectively, these data suggest that acetaminophen-induced nephrotoxicity may involve production of reactive oxygen species leading to oxidative stress and lead to an increasing free radical production which ultimately end up cell death in kidney of experimental group 2.

 
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