Paper Information

Title: 

EFFECT OF VITAMIN C ON ECSTASY INDUCED HEPATOXICITY IN RAT

Type: POSTER
Author(s): AHMADZADEH M.*,AHMADI A.
 
 *PUBLIC HEALTH SCHOOL, RESEARCH CENTER OF AHWAZ, JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The substance, 3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy, is an amphetamine derivate. A long duration of action has led to its widespread popularity among teenagers and young adults in recent years. Increasing evidence indicated that this agent produced hepatotoxicity. The aim of the present study was to investigate the effect of vitamin C on ecstasy produced hepatotoxocity. Adult male rats were pretreated with 300 mg/kg vitamin C (vit C). Control group were received vehicle only. 30 min later, animals were given MDMA at doses 0, 10, 20 or 30 mg/kg. The experiments repeated for 7 consecutive days. 24 h later, rats were killed with over dose of sodium pentobarbital. Blood was collected for determination of ALT, AST and ALP. Liver tissues were removed, fixed and processed for light microscopy Results of the present study showed that MDMA produced dose-dependent manner injury in liver cells. Vit C protected cells against MDMA-induced toxicity. These findings further support the view that ecstasy and/or its metabolite (s) may be responsible for rat liver injury. Vit C has potential to protect liver cells against MDMA produced hepatotoxicity.

 
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