Paper Information

Title: 

THE ORAL EFFECTS STUDY OF THE TOLUENE IN ADULT MALE MICE LIVER

Type: POSTER
Author(s): NAZARI M.,SHAMILI S.,DAEIPOUR N.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Toluene (C7H8) is produced in petroleum refining. It's used as raw material in the production of solvent, varnishes, rust inhibitor adhesives, lacquers, perfume, paint and thinner. In regard to the multiple applications of toluene and its poisoning effects, we decided to study its gavages effects on adult male mice liver structure.
Methods: The experiments were done on the adult mice (8 weekly) with mean weight about 30 grams. The treatments mice were orally administered every day (for 28 days) 0/1 cc of olive solution of toluene (0/059, toluene + 0/041 olive oil) at the dose of 1700 mg/ kg of body weight. At the end after dissection and bring out kidney at control and treatment mice, the samples were supported the weight measurement fixation, moulding, section, coloration stages and finally the microscopic structure liver was studied.
Results: in treatment mice are: 1) presence of wideness sinusoid around the hepatocytes indicate liver inflammation. 2) Lack of sufficient interlobe and interlobular bile duct diameters can be the sign of hypoactivity in bile synthesis. 3) The unequal dimension lobules and hepatocyt is some indication of irregularity in blood distributer around the lobules. 4) Increment of binuclear hepatocytes number with regard to mononuclear hepatocyt number is some indicated of liver exciting with the intention of its repairing or it's hyperactivity. 5) Increase of macrophage cells.

 
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