Saprophytic Gram-positive bacteria in the genus Streptomyces have been shown to have characteristics which make them useful as biocontrol agents against pathogens. These characteristics include the production of secondary metabolites and biologically active substances of high commercial value such as enzymes and antibiotics. Streptomyces spp. is of medical and industrial importance because they synthesize antibiotics. Over 50 main antibiotics have been isolated from Streptomyces spp., including streptomycin, neomycin, chloramphenicol and tetracyclines. To combat toxins accumulation in the environment, in recent years, biological control has offered an environmentally friendly alternative to the use of antimicrobials for controlling infectious diseases of plants. In this regard, a collection of about 100 Actinomycete isolates was screened for the ability to produce metabolites that inhibit fungal growth as Pyricularia oryzae. This pathogen produces picolinic acid and pyricularin toxins. There is evidence that relationship between these toxins and some human diseases exists. Some strains of streptomyces showed strong in vitro antagonistic activity against the pathogen in Agar disc and Well- diffusion methods by producing extracellular antifungal metabolites. Control of plant pathogens with non toxic measurements will provide safer environment and less toxic residual-effects in humans.