Paper Information

Title: 

NITRIC OXIDE INTERFERENCE ON WITHDRAWAL SYNDROME IN MICE

Type: POSTER
Author(s): MAZI H.,MOSLEMI M.*,SADEGHI G.
 
 *URMIA VETERINARY FACULTY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: in this study the effect of nitric oxide were examined on withdrawal syndrome(jumping and amount of feces and urine) using l-arginine (NO percursor) N(G)-nitro-L-arginine methyl ester (L-NAME, a non-specific inhibitor of nitric oxaide synthase) and nitroglycerin(an NO donor)in morphine dependent Bulb-c mice.
Method: morphine dependency was induced by subcutaneous injection of morphine (5mg/kg & 7.5 mg/kg) twice a day for three days. Physical dependence to morphine was observed by precipitating a withdrawal syndrome with naloxone (20mg/kg,s.c.). l-arginine, L-NAME, MB & nitroglycerin were injected subcutaneously 90 minutes after administration of morphine and 30 minutes before injection of naloxone. Jumping as well as amounts of feces and urine were measured during 30 minutes after naloxone administration.
Results: results showed that l-arginine significantly increased the times of jumping and L-NAME decreased the symptoms.
Conclusion: concluded that inhibition of NO pathway in the morphine-dependent persons who are under withdrawal treatment may decrease the signs which may suffer the patients.

 
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