Paper Information

Title: 

THE EFFECT OF TOPIRAMATE ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE (CPP) IN MALE MICE

Type: POSTER
Author(s): FAROKHI F.,POURNAGHASH TEHRANI S.,SAHRAEI HEDAYAT
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: It has been shown that the anticonvulsant drug, Topiramate has modulatory effects on both GABAergic and Glutaminergic neurons. It enhances the activity of GAB Aergic system and conversely, inhibits Glutaminergic system. So, it can reduce the euphoric effects of abused drugs. Given the aforementioned activities of Topiramate the present study examined the ability of Topiramate to inhibit morphine- induced CPP, which could be useful in reducing the euphoric effects of abused drugs namely, morphine, thereby be utilized in the treatment of drug abuse.
Method: A dose- response curve for morphine (1, 10, 20mg/kg) and Topiramate (8, 20, 120mg/kg) was assessed. In order to determine the most effective dose for establishing CPP. During the acquisition phase on conditioning days. Subjects were first given Topiramate prior morphine. As such, the effect of Topiramate on the acquisition of morphine-induced CPP was determined. During the expression phase, on conditioning day’s morphine was injected by itself and on test day, Topiramate was injected before the experiment. As such, the effect of topiramate on the expression of morphine-induced CPP is assessed.
Results: The results showed that Topiramate had an inhibitory effect on the acquisition and expression of morphine-induced CPP. And this effect was at its highest level on the dose 80 of topiramate. Therefore, these results indicate that Topiramate can reduce the euphoric effects of morphine and can induced prevent the induction of morphine-induced CPP.

 
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