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Paper Information

Title: 

THE COMPARISON OF VAGINAL AND ORAL "BROMOCRIPTINEE" FORM VIEWPONIT OF SIDE-EFFECTS AND COUNTINUATY OF USE FOR PATIENTS WHO COME TO GYNECOLOGIC CLINICS

Type: POSTER
Author(s): KAHNAMOUEI F.,AMANI F.,MOHAMMADI S.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Hyperprolactinemia is a disorder which is presented in clinical forms of galactoria unfertility, periodical disorders and hirsutism PMS. Bromocriptine is a Dopamine agonist and a drug for its cure. Because of the continuity of using (even for several years) tolerance of patients for drug is important. The present study indicats us the side-effects and endurance level of patients to Bromocriptinee for two forms of oral and vaginal use.
Methods: In this single-blinded clinic trail, cases of study were patients coming to gynecologic clinics with complain of galactoria, hirsutism, periodical disorders and unfertility. The sample mass was 180(two 90 members) and the period of study was two years. Cases were divided in two groups of oral and vaginal and before the study their vagina was checked systematically to indicate other complications. After assurance of healthy of other systems, drug was prescribed in forms of oral and vaginal. For each group, when we reached to number of 90th. The study was stopped. The data was collected on the basis of planed questionnaire and analyzed by using the statistic software of SPSS.
Results: This study cleared the side-effects of Bromocriptine in oral-forms were %100 and for vaginal-forms were %43/2. Most of the side-effects in oral-forms was nausea (vomiting) %38/9 and in vaginal form was vaginal itching (%22/3) .Vertigo in oral-forms was more than vaginal-forms (%27/8 to %2/3). Hypotention was seen in %11/2 of oral forms but not in vaginal-forms. More than %51/2 of oral-forms had more than one side effect. The most of these in tow groups had been seen during the first ten days (%37/8 and %66/7). Intensity of side effects in %31/2 of oral-forms and %11 of vaginal forms were so that resulted to stopping the drug use.
Conclusion: There is a significant difference between incidence intensity and kind of drug complications in the forms of oral and vaginal use of Bromocriptine and tolerance and duration of drug use in vaginal-forms is more than oral-forms.

 
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