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Paper Information

Title: 

THE METABOLIC EFFECTS OF PDE INHIBITORS IN IMMATURE BALB/C MICE

Type: POSTER
Author(s): SABERI KARIMIAN M.*,SHAFIEINIK R.,PARIZADEH S.M.R.
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Phosphodiesterase enzymes (PDEs) play an important role in regulation of intracellular levels of cAMP and cGMP. They are divided into 11 families. In this study, the metabolic effects of IBMX (a non-selective PDE inhibitor), amrinone, MC7 and MC9 (selective PDE3 inhibitors) were investigated in balb/c mice.
Methods: The balb/c mice (10-12gr) were divided in groups of 5 to 10. They had freely access to water and food. Each mouse was weighted every day and leaved with no treatment (C1), or injected normal saline (C2) or 1 mg/kg drug for one week. Then mice were sacrificed and their bloods were collected from heart. The serum of each sample was seperated and freezed in -18oC for subsequent measuring of glucose, cholestrol and triglyceride concentration.
Results: There was no difference between growth pattern (GP) of male and female mice. Daily administration of normal saline decreased growth in first 3 days. In the presence of amrinone, the GP was first similar to C2 and then increased. IBMX did not change GP. In presence of MC7, the GP was extremely decreased and then returned to C2 levels, While, the effect of MC9 on GP was similar to the effect of C2. IBMX increased cholestrol, triglyceride and glucose significantly, whereas amrinone decreased glucose and cholestrol significantly. MC7 and MC9 produced no significant effect.
Conclusion: Stress decreases the growth. Adaptation to environment is produced after 3 days. Increasing the growth by amrinone in first phase, may be because of decreasing the stress effect. Diminish of growth by MC7 may be related to the augmentation of stress effect. Different effects of drugs in concentration of blood factors remain to more research.

 
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