Paper Information

Title: 

TRANSPORT KINETIC OF TERBUTALINE SULFATE THROUGH BOVIN BUCCAL MUCOSA

Type: POSTER
Author(s): EMAMI J.,VARSHOUSAZ ZH.,ISAEI A.*
 
 *DEPT. OF PHARMACEUTICS, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Due to extensive first pass metabolism in the liver and gut wall only a very small portion of terbutaline sulfate reaches systemic circulation. Frequent administration of the drug, due to the short elimination half life, is also required. A novel buccoadhesive controlled-release system of this drug could both by pass the first pass hepatic metabolism and overcome frequent administration of oral formulations. In the light of above considerations, the assessment of transport of this drug via buccal mucosa before any formulation development is imperative.
Methods: The bovine mucosa layer was clamped between donor and receiver chamber of a Franz diffusion cell at 37oC±0.2. After equilibration, the receiver chamber was replaced with fresh krebs buffer solution (pH = 6.6) and the donor chamber with 2 ml solution of drug (1.5 mg/ml). At different time intervals, aliquots were collected from receiver compartment and drug concentration was measured spectrophotometrically at 207 nm. Permeability coefficient and transport kinetics was assessed using zero
)( and first order) ) kinetic models.
Results: No lag time or initial burst transport was observed. R-squared values for zero and first order were 0.889 ± 0.047 and 0.928±0.024, respectively. First order equation and transport rate constant of drug transport were found to be y=(-0.0124±0.004) x+ (1.0279±0.245) and 0.0124±0.004, respectively.
Conclusion: Terbutaline transport through bovine buccal mucosa follows first order kinetics indicating that the transport does not require energy, is not a saturable carrier mediated process and is concentration dependent. Therefore, drug transport would not be the rate limiting step in absorption process which allows design of a novel buccal delivery system for terbutaline.

 
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