Paper Information

Title: 

EVALUATION OF NOCICEPTIVE EFFECT OF TAMARINDUS INDICIA SEED AQUEOUS EXTRACT ON TAIL FELICK REACTION TIME ON FRUCTOSE-FED RATS

Type: POSTER
Author(s): SHAHRAKI A.R.,SHAHRAKI M.R.,MIRSHEKARI H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Target & Aimee: Metabolic syndrome is a metabolic disorder that affects the diabetic mellitus pathophysiology and caused insulin resistance, and alters the cell excitability. This study was performed to evaluate the nociceptive effect of Tamarindus indicia seed aqueous extract on tail felick reaction time on fructose-fed rats.
Material & Methods: The experiment was performed on 30 Wister-Albino male Rats that equally divided in sham control, first test group which received fructose-enriched of water and second test group which received fructose-enriched of water and Tamarindus indicia seed aqueous extract (TSE). At the end of experiment, tail felick reaction time was measured and then animals were anesthetized, sacrificed, and blood samples were collected. Serum insulin, glucose and DHEAS were measured. Obtained data were analyzed by SPSS software, via ANOVA and turkey tests. Results were expressed by mean±SD and statistical different were significantly if P<0.05.
Results: The tail felick reaction time, insulin and insulin resistanc value in that group which received fructose-enriched of water and
Tamarindus indicia seed aqueous extract did not significantly different compared with those of shame control but significantly decreased compared with those of first test group that received fructose-enriched of water(P<0.05), but DHEAS value in this group were significantly increased compared with those of sham control and first test group which received fructose-enriched of water
Conclusion: These results indicated that Tamarindus indicia seed aqueous extract can affect the tail felick reaction time in fructose-fed, rats.
Future studies will probably show the exact mechanism.

 
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